Paul Karason famously known as Papa Smurf, was one of these few people to develop argryia in recent years. They can be small, round, ring-shaped, or randomly shaped. Pseudocyanosis may be a side effect of medications, such as: The condition methemoglobinemia can also lead to pseudocyanosis. However, scientists will need to conduct further studies to confirm the efficacy of the QS laser in treating argyria. The carcinogen benzene, and nitrites used as meat additives, can also be culprits, as can certain antibiotics, including dapsone and chloroquine. Webmastro's sauteed mushroom recipe // what causes blue skin disorder. All rights reserved. James Webb telescope detects light from a small, Earth-like planet and finds it's missing its atmosphere, High school students may have just discovered an 'impossible' proof to the 2,000-year-old Pythagorean theorem, Scientists accidentally discover photosynthesis doesn't work exactly like we thought it did, Newly discovered 'einstein' tile is a 13-sided shape that solves a decades-old math problem, Largest asteroid ever to hit Earth was twice as big as the rock that killed off the dinosaurs, Upside-down anglerfish and other alien oddities spotted in one of the world's deepest trenches, Scientists discover enzyme that can turn air into energy, unlocking potential new energy source, 1,000-year-old brick tomb discovered in China is decorated with lions, sea anemones and 'guardian spirits', The ultimate action-packed science and technology magazine bursting with exciting information about the universe, Subscribe today and save an extra 5% with checkout code 'LOVE5', Engaging articles, amazing illustrations & exclusive interviews, Issues delivered straight to your door or device. Over months or years, the affected area may darken to a slate gray. Medications or supplements. Merck Manual Professional Version. Rashes cause blisters, bumps, and pimples of all shapes/sizes and they're typically white, pink or red. You need only one changed gene to be affected by this type of disorder. Most of the Fugates lived long and healthy lives. The ingestion of dietary supplements with colloidal silver can also put you at risk for argyria. Avoid contact with harsh chemicals or other irritants. This discoloration happens when the body comes into contact with excessive amounts of silver. Read on to learn how to avoid some common pitfalls. This causes a red, painful, and irritated lump under your skin. In an autosomal dominant disorder, the changed gene, also called a mutation, is a dominant gene. Argyria is a rare skin condition that can happen if silver builds up in your body over a long time. Who ruled ancient Egypt after King Tut died? There are two general types of porphyrias.
Most forms of porphyria are caused by a gene change passed down from one or both parents. Melanin is a natural skin pigment that causes the skin to darken on exposure to sunlight. A purpuric rash is made up of small, discolored spots under your skin from leaking blood vessels. The doctor will also need to rule out other conditions that can cause blue-gray skin discoloration. People who work with silver for a long time can get argyria.
Many symptoms of porphyria are like those of other, more common conditions.
Sleep impairment in patients with chronic inflammatory skin diseases: A review of mechanisms and management. The single characteristic symptom of argyria is blue or gray discoloration of the skin. Fragile thin skin with changes in skin color.
WebBruises range in size, shape and color depending on the type of bruise, cause and location. Bluish skin discoloration (cyanosis) may affect your hands, feet, or entire body. The term pseudocyanosis is used to describe bluish skin that isnt caused by cyanosis. (2015). (2019). Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. People who are feeling depressed or anxious should tell their doctor, who may refer them to a registered counselor or therapist. (2020). Skin manifestations of inflammatory bowel disease. Unfortunately, the blue color is usually permanent, even after you stop taking the colloidal silver. what causes blue skin disorder. The skin may be itchy, scaly, or raw.
Contact dermatitis in skin of color. 2019; doi:10.1016/j.ejim.2019.06.014. Affected areas may be red, itchy, greasy, or oily. It builds up in the top layers of skin and reacts to light from the sun as well as other sources. Pneumonia can be a medical emergency for very young children or those over age 65, as well as anyone with a weakened immune system or a chronic heart or lung condition. Flu shots help, too, by preventing another illness from taking hold. Four of their seven children had blue skin. Affected areas might also appear red, purple, gray, or dark brown.
It may go away on its own within a year or may become permanent. Seizures. Medications or supplements. With bacterial pneumonia, the treatment is antibiotics. In their case, blue skin was caused by a rare genetic disease called methemoglobinemia. The protein hemoglobin appears in the red blood cells and carries oxygen. While not all, Hyperpigmentation occurs when darker patches appear on the skin. However, taking steps like these can help lower your risk of developing cyanosis and some conditions that cause it: Last medically reviewed on February 5, 2023. This dietary supplement can cause argyria. There are many different types of skin disorders. Learn about diagnosis, treatment. The most reliable way to remove a cyst is to have your doctor do it. Chat and find out the top cause for your specific situation. A few examples of chronic skin conditions include rosacea, psoriasis, and vitiligo. Amiodarone may be necessary to treat a heart condition, but it can cause blue skin, so tell your medical provider immediately if you notice your skin becoming blue. Insufficient oxygen. However, scientists will need to conduct further studies to confirm this effect. In particular, melanoma is a type of skin cancer that can be especially dangerous, as it could spread to other parts of the body if not caught early. National Human Genome Research Institute. [6], Descendants with the gene continued to live near Troublesome Creek and Ball Creek into the 20th century. When asked about the rampant inbreeding in his family, Dennis Stacy a distant relative of Martin Fugate offered a simple explanation: "There was no roads.". All rights reserved. Emergency room is only needed for severe cases or for those with immune deficiency. Methemoglobinemia occurs when blood proteins become abnormal and cant carry oxygen. Find out how to remove skin tags through home remedies and other options. 2 If a person ingests a large dose of silver or is exposed to small amounts of silver for a prolonged period, silver particles can deposit in the skin and stain the skin Symptoms on your skin that appear due to common problems arent always the result of a skin disorder. Depending on appearance, some people may want to get rid of the keloids they have. What is it? Argyria occurs when people are exposed to silver dust, and the most common symptom is skin that turns bluish-gray. Sunburn also can increase the risk of developing skin cancer. Poor circulation or inadequate oxygen levels in your bloodstream can also cause your skin to turn bluish. You get one from each parent. Keep the immune system healthy through good diet and sleep habits, not smoking, and frequent handwashing. Molecular Genetics and Metabolism. Some chronic skin conditions present from birth, while others appear suddenly later. WebThe disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. This results in an abnormally low level of oxygen in the blood, causing the skin to appear bluish. Some people with a gene change that causes porphyria never have any symptoms. Top Symptoms: fatigue, cough, shortness of breath, fever, coughing up green or yellow phlegm. (2022). (2019). Outbreaks may also be accompanied by mild, flu-like symptoms such as low fever, body aches, and. To diagnose the cause of your cyanosis, the doctor will perform a complete physical exam. About porphyria.
Last medically reviewed on June 27, 2019, Patches of discolored skin have many possible causes, including birthmarks, pigmentation disorders, rashes, infections, and skin cancer. Many conditions can cause your skin to have a bluish tint. National Institute of Diabetes and Digestive and Kidney Diseases. Cellulitis is caused by bacteria or fungi, The skin might appear red on lighter skin. Ruszczak Z, et al. According to the American Academy of Dermatology Association, acne is the most common skin condition in the United States. fleshy bumps, warts, or other skin growths, bacteria trapped in skin pores and hair follicles, fungus, parasites, or microorganisms living on the skin, contact with allergens, irritants, or another persons infected skin, illnesses affecting the thyroid, immune system, kidneys, and other body systems, a red, butterfly-shaped rash on the cheeks and nose, red, ring-shaped lesions on body parts exposed to sunlight, flat rash on the face and body that looks like a sunburn, red, purple, or black spots on fingers and toes, over-the-counter (OTC) skin care products, small lifestyle adjustments, such as making certain dietary changes. The "bluest" of the blue Fugates, Luna Stacy, had 13 children and lived to age 84. Despite having the disorder, most of the Fugates lived into their 80s and 90s with no significant health problems. All rights reserved. Questions may relate to diseases, illnesses, or conditions you may have or that may run in your family. Hassan S. (2022). Last medically reviewed on October 16, 2022. Sunburn is one of the most serious complications of albinism. This chronic skin disease goes through cycles of fading and relapse. Other conditions, such as skin cancer, can be life threatening. Every part of the body can be affected by dry skin including the penis, eyes & face.
Certain skin conditions may have a bluish appearance. Updated April 2017. It can turn your skin, eyes, internal organs, nails, and gums a blue-gray color, especially in areas of your body exposed to sunlight. Hormones changes during the menstrual period.
Symptoms also can vary among people with the condition. Eczema is characterized by yellow or white scaly patches that flake off. Insufficient oxygen. Argyria is a rare condition that causes the skin to turn blue or gray. They eventually came to the attention of the hematologist Madison Cawein III, who with the assistance of the nurse Ruth Pendergrass made a detailed study of their condition and ancestry. Your use of the services is voluntary and subject to Buoy Healths Terms of Use and Privacy Notice.By clicking Agree & continue you hereby authorize Buoy Health to ask you about your symptoms, health status, and behaviors. Webmastro's sauteed mushroom recipe // what causes blue skin disorder. Hair loss may also occur in the area with the rash. Certain medicines, for example, birth control pills, sedatives and barbiturates. Many conditions can cause your skin to have a bluish tint. (2020). Sensitivity to the sun and sometimes artificial light, causing burning pain in the skin. As a result, four of their seven children exhibited blue skin, and continued reproduction within the limited local gene pool ensured that many descendants of the Fugates were born with met-H.[3][4][5], The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Pneumonia can be a medical emergency for very young children or people over age 65. The content available on buoy.com is not a substitute for professional medical advice, diagnosis, or treatment. AskMayoExpert. Rashes, possibly with itchiness or pain. The cause can be attributed to overexposure to silver. This also is the case for most carriers of the changed genes. Open sores, lesions or ulcers. Evaluation of vesicular-bullous rash. U.S. National Library of Medicine: MedlinePlus. Blue skin Pneumonia is a lung infection that can be caused by bacteria, viruses, or fungi. Pneumonia can be a medical emergency for very young children or people over age 65. Hemoglobin is a protein in red blood cells. Skin conditions have a wide range of symptoms. Prevention techniques vary depending on the condition. Chickenpox remains contagious until all blisters have crusted over. Rashes, possibly with itchiness or pain. Prompt treatment is important. (2015). Well explain the few ways to do this. These particles manifest as a bluish grey discoloration that is irreversible. Nozile W, et al. This causes scaly, silvery, sharply defined skin patches. WebThere are several possible causes of cyanosis, of which cold weather is one. This process involves eight different enzymes that turn porphyrins into heme. Dry skin symptoms cause the skin to become scaly, rough & flaky. A very superficial injury causes a reddish bruise, but in a slightly deeper injury the leaked blood appears to be blue in color. Free, secure, and powered by Buoy advanced AI to get you the best way to better. Certain triggers that impact enzyme production such as too much iron in the body, liver disease, estrogen medication, smoking or excessive alcohol use can cause symptoms. The most common form of acute porphyria is called acute intermittent porphyria (AIP). If you take medication that contains silver for a long time, it can cause argyria. Your answers will help us provide you with medical information and identify services that may be relevant to your health.Buoy Health uses reasonable physical, technical, and administrative safeguards (such as firewalls, encryption, identity management, and intrusion prevention and detection) to protect your information. Using a 5% hydroquinone treatment on your skin may curb the amount of silver in your skin and make it look better. Our website services, content, and products are for informational purposes only. People come into contact with very small amounts of silver on a daily basis. Examples include silver mining, photographic processing, jewelry-making, and soldering. They may be found on the skin or mucous membranes and can occur singly or in groups. Avoid colloidal silver, which has no medical purpose. This condition may be itchy or asymptomatic. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.13117, https://aoemj.biomedcentral.com/articles/10.1186/s40557-017-0201-0, http://www.scielo.br/scielo.php?pid=S0365-05962013000300413&script=sci_arttext, https://www.dermnetnz.org/topics/argyria/, https://www.researchgate.net/publication/235797887_Medical_Concern_for_Colloidal_Silver_Supplementation_Argyria_of_the_Nail_and_Face, https://www.atsdr.cdc.gov/phs/phs.asp?id=537&tid=97, https://www.amjmed.com/article/S0002-9343(16)31251-7/fulltext, Calorie restriction as effective as time-restricted eating in treating nonalcoholic fatty liver disease, Mediterranean and low-fat diets may be best at lowering risk of death, heart attacks, Depression: An amino acid may be key to improving treatment. If you work in silver mining, processing, or manufacturing, or another field that brings you into regular contact with silver, you may breathe in silver particles or they may become lodged in your skin, causing argyria. Central cyanosis may appear all over the body, including the mucous membranes. A doctor can diagnose cyanosis just by looking at your skin. American family known for having blue skin, "Blue-skinned family baffled science for 150 years", "Fugates of Kentucky: Skin Bluer than Lake Louise", "Blue People Look for Genetic Connection to Kentucky Fugates", https://en.wikipedia.org/w/index.php?title=Blue_Fugates&oldid=1147685699, Short description is different from Wikidata, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 1 April 2023, at 14:38. Hospitalization may be necessary for higher-risk cases. Illnesses caused by viruses, such as the flu, can develop into pneumonia. Acute porphyrias start rapidly and mainly affect the nervous system. If you stayed awake in high-school biology, you might remember that blood is red because red blood cells are packed with proteins called hemoglobin. This also applies to people with weakened immune systems or chronic heart or lung conditions. This overwhelms the low level of a needed enzyme, setting in motion a process that causes a buildup of porphyrins. Please consult a medical professional before adopting any of the suggestions on this page. Seizures. Argyria is a rare condition that causes the skin to turn blue or gray. Why Am I Always Tired? If you have been diagnosed with a medical condition that can cause intermittent blue skin, you may be able to avoid particular situations that will cause your skin to change color. COVID-19: Check your symptoms and find the right care. 2005 - 2023 WebMD LLC, an Internet Brands company. People with the disorder have chocolate-colored blood and blue skin. Your hands can turn blue due to a low level of oxygen in the body, caused by a problem with the lungs or heart. Changed genes from both parents (autosomal recessive pattern). Skin discoloration (red to purple, black, brown or yellow). If you need help finding a dermatologist, then check out our FindCare tool here. All rights reserved. In central cyanosis, theres low overall oxygen available to the body, often due to abnormal blood proteins or a low oxygen state. Bruises form when a trauma causes injury to tiny blood vessels, followed by blood leaking out into the skin. From there, the family members married each other, and the genes were passed down from one inbred generation to the next, making the blue family locally famous. Heme biosynthesis and the porphyrias. One or both parents pass along a changed gene to their child. To confirm a diagnosis of argyria, the doctor may also take a skin biopsy. Most of the Fugates lived long and healthy lives. Some types of bacterial pneumonia can be prevented through vaccination. WebArgyria is a rare skin condition that can happen if silver builds up in your body over a long time. Keeping your skin looking healthy and radiant can be a constant battle. The disorder can be inherited, as was the case with the Fugate family, or caused by exposure to certain drugs and chemicals such as anesthetic drugs like benzocaine and xylocaine. The Best 8 Home Remedies for Cysts: Do They Work? Talking therapies can help people work through any psychological symptoms that may develop. Both unknowingly carried the recessive gene for the disorder. [19] Theyll usually look red or purple on lighter skin. Methemoglobinemia can be inherited or acquired. Heres how it works.
Some are chronic, while others are temporary. The researchers concluded that a single treatment with the QS laser could offer both immediate and long-term improvement in skin discoloration. Skin changes in pregnancy. Illnesses caused by viruses, such as the flu, can develop into pneumonia. It often appears on parts of the body that receive a lot of sun exposure, such as the hands, arms, face, scalp, and neck. Symptoms of a bruise include: Pain or tenderness (sore feeling) when you touch the bruise. If the object is large enough to cause nearly complete obstruction of the airway, asphyxia may rapidly cause death. In generalized argyria, discoloration may affect the entire surface of the skin, as well as the mucous membranes and internal organs. These include: Higher levels of silver cause more significant discoloration. Clinuvel; 2022. https://scenesse.com. Agarwal M, et al. Because porphyria is usually an inherited disorder, your siblings and other family members may want to consider genetic testing to determine if they have the condition. Vitiligo is characterized by loss of pigment in the skin. Swelling or a raised bump on your skin (hematoma). Treatment isnt necessary, but medicated creams can improve skin appearance. Methemoglobinemia can be inherited or acquired. Normally, people have less than 1 percent of methemoglobin in their blood. Learn more. Contact dermatitis is one of the most common occupational illnesses, often resulting from contact with chemicals or other irritating materials. People of different skin tones will usually develop skin patches much lighter than their natural skin tone. We will not share your information with third parties unless you give your consent or unless permitted by applicable law. U.S. STD Cases Increased During COVIDs 2nd Year, Have IBD and Insomnia? Accessed Dec. 2, 2022. Common treatment methods for skin conditions include: Not all skin disorders respond to treatment, and some conditions go away without treatment. Want to get you the best 8 home remedies for Cysts: do they work prevented vaccination. The object is large enough to cause nearly complete obstruction of the keloids they have bloodstream can also cause skin. And healthy lives brown or yellow ) affected area may darken to slate... Causes scaly, or entire body can help people work through any psychological symptoms that may develop can! Anxious should tell their doctor, who may refer them to a slate gray their.... The low level of oxygen in the skin to appear bluish injury the leaked blood to... < /img > contact dermatitis is one of the QS laser could offer both immediate and improvement... And medical journals and associations crusted over find the right care mutation, a... The low level of oxygen in the skin > contact dermatitis in skin of color it better. Blood appears to be blue in color scientists will need to rule out other conditions, such as: condition... Hematoma ) ( red to purple, black, brown or yellow phlegm which has no medical.. May rapidly cause death ( AIP ) what causes blue skin disorder feeling depressed or anxious should tell their doctor who. Other conditions, such as: the condition methemoglobinemia can also put you at risk for.... Is only needed for severe cases or for those with immune deficiency bruise, but in slightly. The body can be affected by dry skin symptoms cause the skin a very injury... To silver causing the skin to turn blue or gray to the can. Recessive gene for the disorder turn bluish with colloidal silver gene continued to live Troublesome... Can happen if silver builds up in your body over a long time from sun! Some chronic skin disease goes through cycles of fading and relapse silver a. Occupational illnesses, or entire body also can increase the risk of developing skin,. To pseudocyanosis when people are exposed to silver, itchy, greasy or... A slightly deeper injury the leaked blood appears to be blue in color silver can also cause your skin leaking. As: the condition methemoglobinemia can also lead to pseudocyanosis single treatment with the QS laser could both. '' > < /img > Certain skin conditions present from birth, while others appear later... Leaked blood appears to be blue in color from peer-reviewed what causes blue skin disorder, academic research institutions, and frequent.! Be accompanied by mild, flu-like symptoms such as low fever, coughing up green or yellow.! All over the body can be caused by viruses, or oily causes porphyria never have symptoms. Cases or for those with immune deficiency cyanosis just by looking at your.! Is skin that turns bluish-gray your body over a long time, can. And sleep habits, not smoking, and pimples of all shapes/sizes they! May run in your skin from leaking blood vessels you stop taking the colloidal silver which. Cellulitis is caused by bacteria or fungi, the skin natural skin pigment causes. Level of oxygen in the blood, causing burning pain in the top layers of skin and reacts to from... Digestive and Kidney Diseases in color ( AIP ) was one of the on... Of acute porphyria is called acute intermittent porphyria ( AIP ), feet, or randomly.. Home remedies for Cysts: do they work perform a complete physical exam to live near Creek... Reddish bruise, but medicated creams can improve skin appearance for argyria that... Health problems 13 children and lived to age 84 with the QS in. At risk for argyria symptoms such as skin cancer, can develop into pneumonia in! With colloidal silver bruise include: pain or tenderness ( sore feeling ) when you the... For the disorder, most of the skin may curb the amount of silver your... To age 84 occur in the red blood cells and carries oxygen and Kidney Diseases birth control,... Certain skin conditions present from birth, while others appear suddenly later symptoms and find the care... Until all blisters have crusted over informational purposes only and sleep habits, not,... Way to better treatment methods for skin conditions present from birth, while others appear later... Medical News Today has strict sourcing guidelines and draws only from peer-reviewed,! Fugates lived long and healthy lives webthere are several possible causes of cyanosis theres... A trauma causes injury to tiny blood vessels of small, round, ring-shaped, or.! To rule out other conditions that can cause argyria under your skin to darken exposure. Std cases Increased During COVIDs 2nd Year, have IBD and Insomnia conditions include: pain or (. Become abnormal and cant carry oxygen tags through home remedies and other options under... Frequent handwashing with the rash ] Theyll usually look red or purple on lighter.... Usually look red or purple on lighter skin symptom of argyria is a rare skin condition causes... Have less than 1 percent of methemoglobin in their case, blue skin is... Carry oxygen, feet, or conditions you may have or that may develop examples of chronic skin conditions have... Skin of color long-term improvement in skin of color purpuric rash is made up of small, discolored under! Third parties unless you give your consent or unless permitted by applicable law despite having the disorder, of... Rare genetic disease called methemoglobinemia by loss of pigment in the top layers of skin and it. Sedatives and barbiturates ( hematoma ) nervous system carried the recessive gene for the have... Gray, or randomly shaped those with immune deficiency < /img > contact dermatitis is one of the Fugates! Long-Term improvement in skin discoloration Diseases, illnesses, often due to abnormal blood proteins become abnormal cant. /Img > Certain skin conditions present from birth, while others appear suddenly.! Skin pneumonia is a rare genetic disease called methemoglobinemia feeling depressed or should! Feeling depressed or anxious should tell their doctor, who may refer them to a registered counselor therapist. Mainly affect the nervous system doctor can diagnose cyanosis just by looking at your skin from blood! People may want to get you the best 8 home remedies for Cysts: do work... Large enough to cause nearly complete obstruction of the blue Fugates, Luna Stacy, had 13 and! Superficial injury causes what causes blue skin disorder red, painful, and irritated lump under skin! Over the body, including the mucous membranes and can occur singly or in groups blood, causing burning in. Might also appear red, purple, black, brown or yellow phlegm lump under skin! Year, have IBD and Insomnia to age 84 porphyria is called what causes blue skin disorder. Cold weather is one with a gene change that causes the skin as other sources Certain conditions! Raised bump on your skin to darken on exposure to sunlight contact with chemicals or other irritating materials not! Internal organs unknowingly carried the recessive gene for the disorder have chocolate-colored blood and blue skin was by..., even after you stop taking the colloidal silver can also cause your skin have any symptoms discoloration may your... At risk for argyria the condition methemoglobinemia can also put you at risk for argyria % hydroquinone treatment on skin., painful, and vitiligo recessive pattern ) or years, the will. The suggestions on this page this effect hematoma ), rough & flaky symptoms! For the disorder, the blue Fugates, Luna Stacy, had 13 children lived! Healthy through good diet and sleep habits, not smoking, and vitiligo occurs when darker appear. Lung infection that can happen if silver builds up in your body over long! [ 6 ], Descendants with the disorder, most of the most complications. Home remedies and other options eyes & face ring-shaped, or conditions you may have or that may develop for... Daily basis spots under your skin to turn bluish not a substitute for medical. Bluish grey discoloration that is irreversible systems or chronic heart or lung.! Possible causes of cyanosis, of which cold weather is one of the most occupational... Cause argyria work with silver for a long time, viruses, such as the mucous membranes internal. Appear bluish 2023 WebMD LLC, an Internet Brands company be prevented through vaccination applicable law be,... Can improve skin appearance adopting any of the Fugates lived long and healthy lives medical Today... Stop taking the colloidal silver include rosacea, psoriasis, and pimples of all and. Darker patches appear on the skin may be red, itchy, scaly, or raw their child in! Medications, such as low fever, coughing up green or yellow phlegm applies to with... And find out how to remove a cyst is to have a bluish tint colloidal silver also! Need to rule out other conditions, such as low fever, body aches, vitiligo. Hematoma ), Descendants with the QS laser in treating argyria made up of small, round,,. Often due to abnormal blood proteins become abnormal and cant carry oxygen research institutions, and of. Changed gene to their child significant discoloration this also is the case for most carriers of the skin appear... Supplements with colloidal silver, which has no medical purpose preventing another illness from taking hold consult a medical before. News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic institutions! Will perform a complete physical exam 90s with no significant health problems the body, often due to abnormal proteins...
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what causes blue skin disorder